대머리 혁신: 마이크로RNA가 노화된 모낭의 모발 성장을 자극합니다.

Northwestern University 작성2023년 6월 8일

노스웨스턴 의학 과학자들은 노화된 모낭 줄기 세포의 경직성이 모발 성장을 방해한다는 사실을 발견했습니다. 그들은 작은 RNA인 miR-205를 사용하여 이 세포를 부드럽게 하면 쥐의 모발 성장을 자극한다는 것을 발견했습니다. 향후 실험에서는 국소적으로 전달된 miR-205가 잠재적으로 인간의 모발 성장을 촉진할 수 있는지 여부를 테스트할 것입니다.

마이크로RNA로 딱딱해진 모낭줄기세포를 부드럽게 하면 모발이 다시 자란다.

나이가 들수록 관절이 뻣뻣해지고 움직이기가 더 어려워지는 것처럼, 모낭 줄기세포도 뻣뻣해져서 머리카락이 자라는 것이 더 어려워진다고 새로운 노스웨스턴 의학(Northwestern Medicine) 연구에서 보고했습니다.

그러나 모낭의 줄기세포가 부드러워지면 머리카락이 생성될 가능성이 더 높다는 사실이 과학자들의 발견입니다.

Northwestern scientists discovered how to soften up those stem cells to enable them to grow hair again. In a study in mice published recently in the journal PNAS, the investigators report that they can soften the stem cells by boosting the production of a tiny RNARibonucleic acid (RNA) is a polymeric molecule similar to DNA that is essential in various biological roles in coding, decoding, regulation and expression of genes. Both are nucleic acids, but unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases—adenine (A), uracil (U), cytosine (C), or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA)." data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]"> 세포의 경도를 완화시키는 RNA, miR-205. 과학자들이 더 많은 miR-205를 생산하기 위해 줄기세포를 유전적으로 조작했을 때, 젊고 늙은 쥐의 모발 성장이 촉진되었습니다.

"They started to grow hair in 10 days," said corresponding author Rui Yi, the Paul E. Steiner Research Professor of Pathology and professor of dermatology at Northwestern UniversityEstablished in 1851, Northwestern University (NU) is a private research university based in Evanston, Illinois, United States. Northwestern is known for its McCormick School of Engineering and Applied Science, Kellogg School of Management, Feinberg School of Medicine, Pritzker School of Law, Bienen School of Music, and Medill School of Journalism. " data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]"> 노스웨스턴대학교 파인버그 의과대학. "이것은 생성되는 새로운 줄기세포가 아닙니다. 우리는 기존 줄기세포를 자극하여 모발이 자라도록 하고 있습니다. 많은 경우 줄기세포가 남아 있지만 모발을 생성하지 못할 수도 있습니다.

"우리의 연구는 세포 역학을 조절하여 모발 성장을 자극할 수 있는 가능성을 보여줍니다. 나노입자를 통해 마이크로RNA를 피부에 직접 전달할 수 있는 가능성 때문에 다음으로 국소적으로 전달된 miR-205가 생쥐에서 모발 성장을 먼저 자극할 수 있는지 여부를 테스트할 것입니다. 성공한다면, 우리는 이 마이크로RNA가 잠재적으로 인간의 모발 성장을 촉진할 수 있는지 테스트하기 위한 실험을 계획할 것입니다."

This study was conducted in genetically engineered mouse models. The scientists used advanced microscopy tools, including atomic force microscopy, to measure the stiffness and two-photonA photon is a particle of light. It is the basic unit of light and other electromagnetic radiation, and is responsible for the electromagnetic force, one of the four fundamental forces of nature. Photons have no mass, but they do have energy and momentum. They travel at the speed of light in a vacuum, and can have different wavelengths, which correspond to different colors of light. Photons can also have different energies, which correspond to different frequencies of light." data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]"photon microscopy to monitor cell behaviors in live animals./p>

This study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases grants AR066703, AR071435, AR043380, AR041836, and P30AR075049 of the National Institutes of HealthThe National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. Founded in 1887, it is a part of the U.S. Department of Health and Human Services. The NIH conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. With 27 different institutes and centers under its umbrella, the NIH covers a broad spectrum of health-related research, including specific diseases, population health, clinical research, and fundamental biological processes. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability." data-gt-translate-attributes="[{"attribute":"data-cmtooltip", "format":"html"}]"National Institutes of Health./p>